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Computational Scientist - Ahmed Center for Pancreatic Cancer Research

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Information Technology
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GI Med Onc Rsch Department 710563
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133591 Requisition #
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The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report’s 2018 rankings. It is one of  the nation's original three comprehensive cancer centers designated by the National Cancer Institute.


The Computational Scientist in the Ahmed Center for Pancreatic Cancer Research will focus on analysis of NGS data from human tissue and liquid biopsies. Specifically: 1) SNV and CNV calling using a molecular barcoded targeted panels and WES, 2) transcriptomic analysis of bulk RNA sequencing, 3) analysis of single cell RNA, ATAC and CNV sequencing and 4) integrative analysis of DNA and RNA data.      

 
KEY FUNCTIONS

Works closely with interdisciplinary research team to quantitatively interrogate hypotheses around tumor related genes/pathways to further advance scientific discovery and clinical therapeutic drug development.
 
Independently design, implement, and execute analytical pipelines.
 
Proactively drive the application and development of cutting edge tools to generate and integrate data to support functional genomics, cancer biology, and translational biology.
 
Perform common statistical analysis on biological datasets including parametric and non-parametric tests and data mining.
 
Develop and utilize software for interrogation, visualization, and communication of multidimensional datasets to enable hypothesis generation and data interpretation.
 
Interpret and present research findings.

EDUCATION
Required: Bachelor's degree in Biomedical Engineering, Electrical Engineering, Physics, Applied Mathematics or related field. 
Preferred: Master's degree in Computer Science, Genetics, Bioinformatics, Biostatistics, Engineering, Biomedical Engineering, Applied Mathematics or related field. 

EXPERIENCE
Required: Five years experience in scientific software development/analysis. With preferred degree three years experience required.
Preferred: Strong foundation in bioinformatics including experience in the analysis of NGS data (DNA or RNA, but preferably both). Proficient in PERL/Python, Linux, and statistical computing platforms (R, Matlab, etc). Experience manipulating large volume datasets and experience with high performance computing are essential.Strong foundation in bioinformatics including experience in the analysis of NGS data (DNA or RNA, but preferably both). Proficient in PERL/Python, Linux, and statistical computing platforms (R, Matlab, etc). Experience manipulating large volume datasets and experience with high performance computing are essential.

Experience in genetic/genomic analyses; develop and execute best practice algorithms for next generation sequencing.

Background in molecular/cancer biology and genetics.  Experience collaborating with bench biologists in the areas of cancer biology, cell biology, genomics and/or drug discovery. Experience with pathway analysis, network analysis, and transcriptional regulator networks.

Please include a cover letter, and CV, including list of programming languages and bioinformatics tools used noting the number of years/months used.

It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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