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Research Investigator - Experimental Therapeutics
MISSION STATEMENT
The mission of The University of Texas M. D. Anderson Cancer Center is to eliminate cancer in Texas, the nation, and the world through outstanding programs that integrate patient care, research and prevention, and through education for undergraduate and graduate students, trainees, professionals, employees, and the public.
The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education, and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report’s 2023–2024 rankings. It is one of the nation's original three comprehensive cancer centers designated by the National Cancer Institute.
SUMMARY
The primary purpose of the Research Investigator position is to provide supervision, special training to technical personnel, and/or highly technical work in medical and related research projects, as well as to apply technical expertise to coordinate, design, and carry out research projects while following standard operating procedures for the laboratory.
We are seeking a talented and highly motivated Research Investigator to participate in development of molecular glues and related novel modalities. While we consider various backgrounds, a strong interest in understanding how small molecule tools work, and the desire to tackle a major problem of great significance are essential. The position will allow the candidate to develop valuable new skills and experience in:
Molecular glue discovery
Assay development
Target validation
Targeted protein degradation
Chemical biology
JOB SPECIFIC COMPETENCIES
Laboratory Operations & Equipment
Ensures that daily operations are maintained in adherence with policies, to include: order placement, equipment maintenance, safety, and training other research personnel. Helps laboratory manager teach techniques to graduate students, surgical fellows, and other research personnel.
Research Projects & Data
Plans, organizes, directs, and participates in research experiments. Manually and promptly records research data. Analyzes data, prepares graphs, charts, and/or tables for publications. Knowledge of word processing programs and spreadsheets. Discusses results from each assay to ensure accuracy and comparability with previous results of similar assays and reconciles discrepancies as soon as possible. Reads and discusses selected literature with supervisor and other laboratory personnel. Participates in lab presentations.
Procedure Adherence and Implementation
Maintains lab stock cancer cell lines for cell culture and mouse xenograft studies, to include: growing, expanding, and freezing utilizing sterile techniques. Ability to carry out and learn new in vitro and in vivo assays in the field of molecular biology, biochemistry, and cell biology. Some procedures will require the use of hazardous substrates. Must maintain appropriate environmental surveys for radioactivity and other hazardous materials. Must maintain records of hazardous chemicals and reagents as required. Handles patient tissues, with familiarity of safety procedures. Other duties as assigned.
Other duties as assigned
REQUIREMENTS
Education Required: Bachelor’s degree in one of the natural sciences or related field.
Education Preferred: Master’s degree in one of the natural sciences or related field.
Experience Required: Five years of experience in scientific or experimental research work. With preferred degree, three years of required experience.
Experience Preferred - Proficiency in recombinant protein expression using baculovirus expression system
· Hands-on experience with biochemical/biophysical assays, including TR-FRET, NanoBRET
· Proficiency in flow cytometry-based reporter assays.
· Experience with high-throughput screening (HTS) is highly desirable.
· Candidates with structural biology techniques, particularly cryo-electron microscopy (cryo-EM), are encouraged to apply
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
