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Leukemia - Research 600411
131606 Requisition #
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The University of Texas MD Anderson Cancer Center in Houston is one of the world's most respected centers focused on cancer patient care, research, education and prevention. It was named the nation's No. 1 hospital for cancer care in U.S. News & World Report’s 2018 rankings. It is one of  the nation's original three comprehensive cancer centers designated by the National Cancer Institute.

The Research Scientist applies technical expertise and experience to plan, coordinate, design, supervise and carry out research projects. 




Technical Research  

• Independent animal experimentation using engrafted and transgenic mice models and anti-tumor drugs, analysis of data and application of findings to carry out basic and translational research. 

• Critical thinking abilities, excellent technical skills, strong work ethic and good organizational and communication skills.

• Assist in projects related to the development of optimal in vivo study with particular emphasis on therapeutic evaluation and molecular mechanism of novel agents on AML or breast cancer mouse models in accord with appropriate institutional and regulatory guidelines

• Assists in the development of new procedures and improves upon existing techniques relevant to the research.

• Write technical reports for grant/patent applications and scientific publications

• Design and execution in establishing AML or breast cancer PDX mouse model and transgenic models to determine effects of novel drugs, evaluates research data and develops and revises techniques or approaches to work problems in leukemia mouse models, IVIS bioluminescent imaging, tissue collection, and IHC, etc.

• The position requires a highly motivated individual with technical expertise in molecular and cell biology to conduct highly ambitious projects aimed at targeting therapy on leukemia cells. 

• Collaboration with established and committed investigators is a requirement in this interdisciplinary research.  

•Perform experiments associated with cancer research. Should have knowledge and experience in basic tissue culture, RNA,DNA and Protein isolation from cells and tissues, quantitative RT-PCR, western blot, virus production and stable overexpression or knockdown cell line generation, Flow cytometry and immunohistochemistry.

•Knowledge in cancer metabolism pathways and experience with metabolic assays are preferred. 

•Experience in handling animals (mice) and perform tasks such as tail vein injections, intraperitoneal injections, subcutaneous injections, bleeding the mice for sample collection, bioluminescence imaging, CT scanning, are preferred.


Data Analysis   

•Application of IVIS bioluminescent imaging for leukemia burden or flow cytometry for leukemia engraftment or IHC for leukemia burden

•Design and execution of in vivo studies using mouse model 

•Proficiency in immunological techniques (immunohistochemistry, immunocytochemistry, flow cytometry, etc.) 

•Perform animal work and drug treatment studies – dosing (intra-femoral injection, oral gavage, IP or IV), tissue preparation and sample processing

•Perform necropsies and tissue collection for histopathological evaluation and IHC

•Perform Immunofluorescence and interpretation of results and data analysis 

•Maintains multiple immunocompromised mouse colonies, including breeding, genotyping, and record keeping for all animal strains


Lab Development and Oversight   

•Perform general laboratory functions and procedures including maintaining inventory and operate, calibrate and perform routine maintenance on specialized equipment, ordering supplies, preparing solutions, maintaining cleanliness and safety in a laboratory setting

•Ability to work independently and in a team under minimum supervision

•Train and oversee research technicians and students participating in research in the laboratory

•Excellent analytical, communication, organizational and presentation skills are essential.

•Ability to manage multiple projects simultaneously is essential

•Technical proficiency in standard biochemical, cellular and molecular biology techniques and in in vivo/ex vivo/in vitro immunology approaches

•Strong results-driven personality with high level of enthusiasm, energy and confidence 

Required: PhD in one of the natural sciences or related field or Medical degree. 

Required: With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work.
Preferred: Proficiency in standard biochemical, cellular and molecular biology techniques and in in vivo/ex vivo/in vitro immunology approaches.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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