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Research Scientist - Translational Molecular Pathology

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Research
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Translational Molecular Path 149100
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152263 Requisition #
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SUMMARY

The primary function of the Research Scientist position is to apply technical expertise, experience and creative insights in molecular biology, next generation sequencing, genomics, proteomics, and other Research methods to perform specific experiments designed to improve the functional understanding of processes involved in  pancreatitis and in early and late pancreatic carcinogenesis. This will include to plan, coordinate, design, supervise, carry out manually and/or with automation experiments on samples derived from patients or genetically engineered mouse models, and to analyze and present data from research projects. 

 

 

CORE VALUES

Caring Behaviors

  • Courtesy: Is respectful and courteous to each other at all times.
  • Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; is sensitive to the concerns of our patients and our co-workers.

Integrity Behaviors

  • Reliability: Communicates frequently, honestly and openly.
  • Accountability: Holds self and others accountable for practicing our values.
  • Safety: Models safe behavior (wears badge and personal protective equipment, washes hands, and keeps work area clean and orderly); Notices a safety concern or emergency, understands role and uses proper procedures to report it; Mitigates risk to the institution through sound business practices; Demonstrates ethical and personal responsibility in work and behavior

Discovery Behaviors

  • Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas.
  • Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so.

 

 

 

 

JOB SPECIFIC COMPETENCIES

 

Participate in scientific research projects.
•           Under the supervision of the Principal Investigator, develop and design projects and all experiments related to the project
•           Independently perform all aspects of the experiments, which may include Western blotting, flow cytometry, ELISA, immunohistochemistry, tissue culture, PCR and next generation sequencing.
•           Designs, organizes and performs animal experiments.
•           Perform drug screening and analyze data
•           Participate in adopting new techniques and learning new skills to enhance research efforts.
•           Maintain assertiveness and flexibility in approaching new techniques and responsibilities, utilizing good work habits and time management.
•           Maintain alertness and careful attention to avoid injury to self and others due to chemicals and hazardous materials in the laboratory.
•           Plan and supervise the training of technicians and other laboratory personnel with respect to proper laboratory techniques, the use of laboratory equipment, and safety procedures.
•           Monitor and anticipate laboratory needs in terms of equipment and supplies.
•           Prepare oral and written reports about the progress of various projects.
•           Review the scientific literature regularly to plan the research project.


Maintain good, detailed experimental records, evaluate resulting research data, and present findings.
•           Maintain an up-to-date, organized, and legible laboratory journal that records all experiments in detail and ensure that subordinates do the same.
•           Utilize image analysis system and/or microscope to analyze data and examine results.
•           Compile, write, and submit project results to supervisor.
•           Prepare scientific documents for publication.
•           Present findings of research projects to professional groups.
•           Store data on approved, MD Anderson network drives.

Writing activities.

•           Assist with the preparation of grant applications and preliminary data as requested by the laboratory director.
•           Prepare progress reports for grants and pharmaceutical contracts funding research projects.
•           Prepare scientific manuscripts reporting research findings.
•           Present research findings at laboratory meetings, departmental seminars, and annual conferences.

Work closely with other staff members.

•           Maintain good working relationship with other researchers and technicians
•           Train and supervise new technicians and other laboratory personnel in proper laboratory techniques, the use of laboratory equipment, and safety procedures
•           Explain to staff members the scientific protocols currently being employed in the laboratory
•           Work with trainees including graduate students and postdoctoral fellows
•           Other duties as assigned


 

Laboratory Technical Function  
•           Maintains pancreatic cancer cell lines using sterile technique. Extract protein lysates, DNA and RNA from cells.
•           Performs a broad range of cell and molecular assays involving molecular biology and biochemistry of DNA, RNA and protein, including: IHC, immunofluorescence, western blot, flow cytometry and real time qPCR
•           Perform validation, optimization, and troubleshooting of real time qPCR, next generation sequencing protocols as they relate to DNA and RNA analysis from human and mouse samples.
•           Perform optimization, and troubleshooting of single- and multiplex  (OPAL) IHC, IF stainings and  western blots. 
•           Perform isolation, culturing and downstream in vitro assays of primary cell originating from different cellular compartments of the mouse and human pancreas including: acini isolation, 2D cell cultures, organoid cultures.
•           Perform optimization and troubleshooting of functional assays including: MTT, Incucyte assays, drug screening.
•           Perform molecular cloning with bacteria and CRISPR gene editing.

 

 

Mouse Colony Management 
•           Oversee genetically engineered mouse colonies, mouse breeding schemes, genotyping, observation of in vivo drug studies, obtaining mouse specimens.
•           Assumes shared responsibility for performing mouse genotyping

 

 

Laboratory Maintenance  
•           Assumes shared responsibility for general laboratory maintenance by
a) maintaining procedures and protocols that ensure the quality and integrity of procedures performed,
b) monitoring work flow as it pertains to the need for supplies, equipment maintenance and preparation of stock solutions,
c) keeping ample stock of supplies on hand,
d) following up on orders to ensure organization and accessibility of all reagents.
•           Maintains an excellent working knowledge of all basic laboratory equipment and apparatus.
•           Maintains Lab Functions to include ordering of supplies and ensures lab equipment is maintained in good operating order.

Other duties as assigned

 

Other duties as assigned

 

PhD in one of the natural sciences or related field or Medical degree With PhD, no experience required. With Medical degree, two years of experience in experimental or scientific work. It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html

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