Institute Research Investigator Structural Biology

EDUCATION: 
Required:  Bachelor's degree in biology, biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.

Preferred: PhD in one of the natural sciences or related field or Medical degree.

EXPERIENCE: 

Required:  Six years experience of relevant research experience in laboratory.  With a Master's degree, four years of required experience.  With a PhD in a natural science or Medical degree, no experience required.

Preferred:  Extensive knowledge of contemporary single-particle cryo-EM, and familiarity with X-ray crystallography, nuclear magnetic resonance, and/or structural bioinformatics, as evidenced by a strong publication record in peer reviewed journals.  Extensive experience with cryo-EM sample preparation (eg. vitrobot, Leica) and data collection on modern microscopes (eg. Glacios, Krios, Tundra).  Expert knowledge of the latest single-particle cryo-EM data processing software (eg. CryoSPARC, RELION, etc.) and familiarity with crystallographic refinement software.  Experience using biophysical methods (eg. ITC, SPR, DSF, MST) to evaluate protein-ligand binding affinity, binding kinetics, complex formation, etc.  Experience solving structures of membrane proteins.  Excellent communication, writing, and organizational skills.  Experience working with medicinal and computational chemists.

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